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The Shazhou Uprising of 848 AD, led by Zhang Yichao against the occupying Tibetan garrison, is the historical event Blood Message dramatizes and the inciting incident that sends the Messenger toward Chang'an.
The Tang Empire is the historical setting of Blood Message, picked up in 848 AD during its declining years, with the western prefectures under foreign occupation and word of the Shazhou Uprising racing toward the imperial capital at Chang'an.