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The Terror Realm is described by the Diablo V team as Diablo's own corner of Hell, and the discovery that the player can enter it and survive is said to be where the story really begins.
Sanctuary in Diablo V is a world that has already lost. Blizzard describes it as living through its apocalypse rather than waiting for one, with the Western Continent overrun, no safe towns left, and the landscape itself no longer stable.